Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors.

Moreover, compared with the control group, the proportion of EdU-positive cells was obviously diminished in NSCLC cells after compound 8 treatment for 24 h and exhibited a decreasing trend with the increase of drug concentration, which indicated that the cell number in the proliferative phase was gradually decreased with the increase of administered concentration, and that compound 8 could suppress the cell proliferation in a concentration-dependent manner ( Fig. 2 E, F).

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