The Role of Candidate Polymorphisms in Drug Transporter Genes on High-Dose Methotrexate in the Consolidation Phase of the AIEOP-BFM ALL 2009 Protocol.

Clin Transl Sci · 2025 · PMC11786019 · PMID 39891427

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closest p · 1.6× alpha

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boldest claim

The sentences

borderline significancep = 0.08so close (0.05 < p ≤ 0.1)

The association between SLCO1B1 SNP rs4149056 and relapse risk remained fully significant after multivariate analysis (protective non‐TT genotype: HR: 0.27, CI: 0.08–0.90, p = 0.037), whereas older age and lower clearance retained borderline significance as adverse factors (HR: 2.14 (0.90–5.05), p = 0.08 and 2.18 (0.93–5.07), p = 0.07, respectively, Table 4 , Figure 3 ). 4.

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