Pyrazole derivatives ameliorate synovial inflammation in collagen-induced arthritis mice model via targeting p38 MAPK and COX-2.

Naunyn Schmiedebergs Arch Pharmacol · 2025 · PMC11787049 · PMID 39073417

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considerably significantp < 0.001actually significant

Our study showed that longer duration of treatment with M1E and M1G resulted in considerably significant ( p < 0.001) restoration of MDA (1.87 ± 0.12 and 1.37 ± 0.1, respectively) and SOD (2.36 ± 0.17 and 2.34 ± 0.19, respectively) levels in comparison with indomethacin.

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