Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response.

10 However, many of these patients had underlying malignancies, with several getting chemotherapy/immunotherapy, and, except for a nonsignificant trend with PPM1D mutations, there were no clear mutational associations detected. 10 In a subsequent study of patients without cancer, CH was identified in 33% of 568 patients affected by COVID-19, with DNMT3A and TET2 mutant ( DNMT3A mt and TET2 mt, respectively) CH being most frequent.

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