Burden of esophageal cancer in global, regional and national regions from 1990 to 2021 and its projection until 2050: results from the GBD study 2021.

A decreasing trend of ASIR was detected in 19 regions, with the largest decrease in Central Asia [(estimated annual percentage change) EAPC: -3.49; 95% CI: -3.67 to -3.31] ( Supplementary Table 1 ).

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An increasing trend occurred in Western Sub-Saharan Africa (EAPC: 2.09; 95% CI: 1.87 to 2.31) ( Supplementary Table 2 ).

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