Human Primary Monocytes as a Model for in vitro Immunotoxicity Testing: Evaluation of the Regulatory Properties of TiO₂ Nanoparticles.

Although pretreatment with MDP alone enhanced LPS-based IL-1β release, the presence of TiO 2 reduced this production and enhanced IL-10 production ( Figure 5B ). Additional experiments showed that there was a slight increase in LDH leakage after the pretreatment with the CREB inhibitor 666–15, but at the margin of significance ( Figure 6A ).

also in 31 other papers