CYP2D6 genotype and associated 5-HT<sub>3</sub> receptor antagonist outcomes: A systematic review and meta-analysis.

While there was a positive trend, there was no significant difference between groups (RR: 1.18 [95% CI: 0.66–2.10]; p = 0.570) (Figure 3 ).

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45 For consistency and to determine the majority of alleles with functional changes across populations, studies should include all AMP Tier 1 45 CYP2D6 star alleles (those with population frequencies ≥1%), along with other ones that may be significant within the specific study population.

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