How Useful is Nuchal Translucency in Detecting Chromosomal Abnormalities Missed by Genome-Wide NIPT and What Measurement Threshold Should Be Used?

Prenat Diagn · 2025 · PMC11790515 · PMID 39754320

Europe PMC DOI

hedged sentence

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

borderline significantp = 0.054so close (0.05 < p ≤ 0.1)

The resultant detection rate for major chromosome abnormalities when in combination with a MD was significantly lower than when in isolation, compared to the current study ( p = 0.025) and borderline significant compared with published meta‐analyses ( p = 0.054) [ 2 , 19 , 20 ].

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