Liver diseases: epidemiology, causes, trends and predictions.

Signal Transduct Target Ther · 2025 · PMC11794951 · PMID 39904973

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an increasing trendno p-value reported

Cholangiocarcinoma (CCA), though less common than HCC, has exhibited an increasing trend in the U.K. and the U.S., particularly with intrahepatic forms, while extrahepatic CCA has seen a decline. 121 , 122 The U.S. recorded an increase in intrahepatic CCA incidence from 0.44 per 100,000 in 1973 to 1.18 per 100,000 in 2012. 123 This rise is largely attributed to the increasing prevalenc

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