However, their secretion of tumor-killing cytokines IFN-γ and TNF-α showed a decreasing trend, similar to the control group levels, suggesting that most T cells experienced functional exhaustion and were unable to sustain their anti-tumor effects.
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Anti-PD-L1 blockade facilitates antitumor effects of radiofrequency ablation by improving tumor immune microenvironment in hepatocellular carcinoma.
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The sentences
The PD-L1 expression in the tissue outside the ablation site showed an increasing trend, primarily in tumor cells.