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Stereotactic radiosurgery versus whole-brain radiotherapy for intracranial metastases: A systematic review and meta-analysis.

Surg Neurol Int · 2025 · PMC11799717 · PMID 39926465

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Evidence from prospective trials has demonstrated that postoperative adjuvant WBRT decreases the likelihood of recurrence in the surgical site and lowers the occurrence of new metastases.[ 17 , 28 ] While adjuvant WBRT enhances control over intracranial tumors, it does not provide any proven advantage in terms of longevity and instead negatively impacts the quality of life and cognitive function.[ 5 ] To prevent the harmful consequences of WBRT, there is an increasing trend to use SRS to treat the area where surgery was performed.

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