Carboxylesterase 4A Inhibits the Malignant Biological Behavior of Nasopharyngeal Carcinoma via the PI3K/AKT Pathway.

Technol Cancer Res Treat · 2025 · PMC11800256 · PMID 39912257

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an increasing trendno p-value reported

Additionally, PI3K and phospho-PI3K (P-PI3K) displayed a declining trend in CNE1 but an increasing trend in HONE1 ( Figure 4 ).

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a decreasing trendno p-value reported

Our findings indicated that restoring CES4A expression led to a reduction in AKT and phospho-AKT (P-AKT) expression in CNE1; AKT also exhibited a decreasing trend in HONE1, while P-AKT was downregulated.

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