A population-based study on the burden of hospitalized pediatric pneumococcal disease in Taiwan before and after the introduction of 13-valent pneumococcal conjugate vaccine into the childhood immunization program in 2015.

While ITSA results for quarterly AOM IRs among children < 18 years did not show a significant change in baseline IR, a marginally significant increase in trend of IR was observed in the post-PCV13 period, compared with pre-PCV13 period (Fig. 3 ; Table 1 ).

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