SPA<sub>GRM</sub>: effectively controlling for sample relatedness in large-scale genome-wide association studies of longitudinal traits.

Nat Commun · 2025 · PMC11803118 · PMID 39915470

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closest p

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extremely significantno p-value reported

28 ), we still recommend using 1e-6 as the threshold because extremely significant HWE test p value may also indicate potential quality control issues.

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