Organismal complexity strongly correlates with the number of protein families and domains.

In addition, in all five datasets (all 81 organisms, eukaryotes, animals, and Viridiplantae), the correlation between the number of cell types and the number of protein families remained significant or marginally significant after controlling for genome size (all 81 organisms: ρ = 0.209, P = 0.063; eukaryotes: ρ = 0.434, P = 0.0006; animals: ρ = 0.337, P = 0.100; Viridiplantae: ρ = 0.675, P = 0.011), the number of genes (all 81 organisms: ρ = 0.541, P = 2.19 × 10 −7 ; eukaryotes: ρ = 0.681, P = 2.99 × 10 −9 ; animals:

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