Neomorphic leukemia-derived mutations in the TET2 enzyme induce genome instability via a substrate shift from 5-methylcytosine to thymine.

Proc Natl Acad Sci U S A · 2025 · PMC11804724 · PMID 39874291

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an increasing trendno p-value reported

Notably, compared to Tet2 WT and KO cells, N1300T cells exhibited significantly higher frequencies of SNVs and Indels, with CNVs showing an increasing trend ( Fig. 4 E and Datasets S4–S6 ).

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