Preoperative prediction of IDH genotypes and prognosis in adult-type diffuse gliomas: intratumor heterogeneity habitat analysis using dynamic contrast-enhanced MRI and diffusion-weighted imaging.

Cancer Imaging · 2025 · PMC11807326 · PMID 39923105

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MR spectroscopy findings on glioma intratumor metabolites have indicated that tumor regions with a high concentration of lactate, a marker of hypoxia, exhibited an increasing trend in ADC values [ 45 ]; hence the elevated ADC levels in Habitat 2 may reflect more severe hypoxia, which correlates with shorter PFS [ 46 ].

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