a trend toward significancep = 0.051
In relation to demographic factors, our study indicates that OL could significantly have more malignant potential in women (RR = 1.39, 95% CI = 1.19–1.62; p < 0–001), with a trend toward significance in patients over 50 years old (RR = 1.57, 95% CI = 1.00–2.48; p = 0.051), which would presumably reach a discriminative significance level if the number of studies analyzing this aspect were increased.