The three rates associated with the inter HL disulfide reduction for the three species, Intact (including IntactR), HHL (including HHLR), and HL, showed a decreasing trend from 6.98 × 10 − 4 to 6.81 × 10 − 5 L ( μmol s ) − 1 .
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Kinetic Modeling of the Antibody Disulfide Bond Reduction Reaction With Integrated Prediction of the Drug Load Profile for Cysteine-Conjugated ADCs.
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