Exosome-membrane and polymer-based hybrid-complex for systemic delivery of plasmid DNA into brains for the treatment of glioblastoma.

These results suggested that apoptosis was induced effectively by pHSVtk/PHR-EM in the glioblastoma animal model and therefore, further induction of apoptosis might not be significant, although pHSVtk/PHR-EM-T7 had higher delivery efficiency than pHSVtk/PHR-EM. 4 Conclusion In this study, pDNA/PHR-EM-T7 was developed for systemic delivery of pDNA into a glioblastoma. pDNA/PHR-EM-T7 had an improved targeting delivery effect to glioblastoma after intravenous administration compared with pDNA/lipofectamine, pDNA/PHR, and pDNA/PHR-EM.

also in 670 other papers