Transdermal microneedle-assisted ultrasound-enhanced CRISPRa system to enable sono-gene therapy for obesity.

Nat Commun · 2025 · PMC11811159 · PMID 39929846

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a decreasing trendno p-value reported

Plasma chemistry analysis consistently showed a decreasing trend in TG and cholesterol levels, along with an increase in free fatty acids (FFA) produced by lipolysis, when treated with MN-MP/aUCP1 plus US enhancement (Supplementary Fig. 9c–e ).

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