Estrogen exerts a significant role on the brain’s neurotransmitter systems, particularly the serotonin (5-HT) system, through estrogen receptors (ERα and ERβ).When estrogen levels decline, there is a decreasing trend in 5-HT 1a receptor levels, while estrogen negatively regulates the 5-HT 2a receptor through ERβ ( Chhibber et al., 2017 ).
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Jiawei Suanzaoren decoction for the treatment of perimenopausal insomnia: clinical observation and experimental study.
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