Immune profiling of the macroenvironment in colorectal cancer unveils systemic dysfunction and plasticity of immune cells.

On the other hand, the expression of PD‐1 in CD8 + Tcm and Tem showed an increasing trend from the top to the bottom layers of the bowel (Figure 3F ).

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We found that CD39 was overexpressed in γδ T cells, CD8 + Tcm cells, CD8 + Tem cells, with a decreasing trend from the epithelial layer to the muscularis propria (Figure 3E ).

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