Altered Gene Expression of Immunity-Associated Genes in Stim1/2 -deficient Mice Among the most downregulated immune-related genes in parotid glands of Stim1/2 K14Cre(+) mice identified by IPA ( Figure 3C and Supplementary Figure S3 ) were the toll-like receptor 8 ( Tlr8 ) ( P < 0.0001) and interferon regulatory factor 7 ( Irf7 ) ( Figure 7A ), Tlr7 was close to significance.
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Loss of STIM1 and STIM2 in Salivary Glands Disrupts ANO1 Function but Does Not Induce Sjogren's Disease.
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