A clear response to treatment with resolution of the aversive behavior strongly supports the clinical relevance of the disease that was targeted with the treatment, e.g., when 21 lame horses were assessed via the RHpE before and after the abolition of their lameness with diagnostic analgesia, there was a highly significant decrease in their overall RHpE behavior score as well as a highly significant decrease across the various individual behavioral traits within the RHpE (head position, tail position, facial expressions, and gait) [ 23 ].
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