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Characterization of Metabolic Patterns in Mouse Spermatogenesis and Its Clinical Implications in Humans.

Int J Mol Sci · 2025 · PMC11816495 · PMID 39940768

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Our findings provide a comprehensive metabolic profile of spermatogenesis and suggest that metabolic alterations may be significant contributors to male infertility, particularly in cases of azoospermia. metabolomics spermatogenesis Leydig cells Sertoli cells azoospermia seminal plasma National Key R&D Program 2022YFC2702800 2021YFC2700302 2021YFC2700501-1 National Natural Science Foundation of China 82221005 82122025 82201763 Natural Science Foundation of the Jiangsu Higher Education Institutions of China 21KJA310007 This research was funded by the National Key R&D Program (grant number 2022YFC2702800 (Y.Y.

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