Red Blood Cell-Related Phenotype-Genotype Correlations in Chronic and Acute Critical Illnesses (Traumatic Brain Injury Cohort and COVID-19 Cohort).

The exceptions were highly significant differences in minimum RBC, HGB, and HCT levels in patients grouped by anemia diagnosis.

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In the COVID-19 sample, a marginally significant effect was observed for the hsa04330 gene set when the threshold for HGB was <the reference level, but below the threshold for HGB < 100 g/L, pronounced effects were observed for the same gene sets (GO-derived and hsa04330) as in the TBI sample.

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The percentage of variance explained (R-squared) in the TBI sample ( Figure 6 A) reached significant values for RBC and HGB and partially significant values for HCT at the final and min–max measurements, with no influence of genetic variables on these dependent variables.

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