JQ1 Treatment and miR-21 Silencing Activate Apoptosis of CD44+ Oral Cancer Cells.

We used RT-qPCR to examine the expression of CCND1 gene (encoding cyclin D1), a crucial cell cycle regulator of the G1/S transition, and found that JQ1 alone and concomitantly with miR-21 inhibition had a highly significant effect on CCND1 downregulation, which is consistent with G1 cell cycle arrest ( Figure 5 d).

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