and PPARG )—the data indicate that the same marker allele is significantly associated and has an effect size of similar direction and magnitude [ 22 ] (the linkage data are less congruent, probably due to power considerations); and 3) for age-related macular degeneration, at least five studies show highly significant association with the same CFH Y402H polymorphism [ 23–27 ] in a region strongly implicated by multiple linkage studies.
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