A significant rebound of SIRT1 and SIRT5 and an increasing trend of SIRT6 and SIRT7 were confirmed in the small intestines of EpCAM −/− mice after administration of gefitinib (Figures 4E and S6D ).
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EpCAM deficiency causes the premature ageing of intestinal stem cells via EGFR/SP1/mTORC1 pathway.
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