Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease.

In step 2 MR, a standard deviation increase in plasma C-terminal COL6A3 levels increased CAD risk in males (OR = 1.63, 95% CI: 1.34–1.98, P = 1.26 × 10 −6 ), whereas females showed a positive trend (OR = 1.18, 95% CI: 0.95–1.46, P = 0.13) (Extended Data Fig. 3c and Supplementary Table 17 ).

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