Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids.

Using human neural organoids as models of early brain development, we could recently show that GCs elicit cell type–specific transcriptional responses and that there is a highly significant enrichment of genes associated with neurodevelopmental delay, ASD, and more common psychiatric disorders among those regulated by GCs, especially in neurons ( 22 ).

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