Abnormal H3K27me3 underlies degenerative spermatogonial stem cells in cryptorchid testis.

Development · 2025 · PMC11829757 · PMID 39745222

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Strikingly, comparison of control and cryptorchid GFRa1 + /KIT − spermatogonia indicated an increasing trend of mRNA for the H3K27me3-lost genes, but not for the H3K27me3-gained genes, in cryptorchid spermatogonia ( Fig. 3D ).

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