highly significantP <0.001
A P -value of <0.05 was considered as statistically significant (*), a P -value of P <0.01 as highly significant (**) and P -values of P <0.001 (***) as extremely significant.
A P -value of <0.05 was considered as statistically significant (*), a P -value of P <0.01 as highly significant (**) and P -values of P <0.001 (***) as extremely significant.