highly significantp < 0.05
The high-dose group showed a highly significant suppression of VEGF, VEGFR1, VEGFR2, and HIF-1α expression ( p < 0.05 and p < 0.0001), with the medium dose also significantly reducing VEGF, VEGFR1, and HIF-1α levels ( p < 0.05 and p < 0.0001) ( Figure 7H ).