Impact of Mild Hypothermia As Adjunctive Therapy in Patients With ST-Elevation Myocardial Infarction: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials.

Catheter Cardiovasc Interv · 2025 · PMC11831718 · PMID 39676437

Europe PMC DOI

hedged sentence

0.0800

closest p · 1.6× alpha

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boldest claim

The sentences

at the edge of significancep = 0.08so close (0.05 < p ≤ 0.1)

Furthermore, in the TH group, an increase at the edge of significance was found in the risk of AF (RR 2.25, 95% CI 0.85−5.95, I 2 = 48.2%, p = 0.08, 5 RCTs, 531 patients), STh (RR 2.46, 95% CI 0.92‐6.57, I 2 = 0%, p = 0.08, 6 RCTs, 525 patients), any bleeding (RR 2.05, 95% CI 0.97‐4.32, I 2 = 0%, p = 0.06, 8 RCTs, 645 patients) (Supporting Information S1: Figures 6–8 ).

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