Profiling antimalarial drug-resistant haplotypes in <i>Pfcrt</i>, <i>Pfmdr</i>1, <i>Pfdhps</i> and <i>Pfdhfr</i> genes in <i>Plasmodium falciparum</i> causing malaria in the Central Region of Ghana: a multicentre cross-sectional study.

22 , 23 Studies on the molecular markers of resistance showed an increasing trend in the prevalence of haplotype Pfmdr 1 N86-F184-D1246 from 2003 to 2010. 24 In another study in the Western region of Ghana, frequencies of the point mutations implicated in the emergence of antifolate resistance were reported to be very high at codons 108, 59 and 51 on the Pfdhfr gene and moderate prevalence at codons 540 and 437 on the Pfdhps gene.

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