Factors to Consider for Synthesis in 1536-Well Plates─An Amide Coupling Case Study for PROTAC Synthesis.

J Org Chem · 2025 · PMC11833857 · PMID 39895090

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may be significantno p-value reported

45 Different Trends Observed when Varying the Solvent Given the results from the mixing protocol experiments indicated that mass transfer played a key role in the success of reactions in 1536-well plates, the role of solvent choice was investigated to determine whether factors such as viscosity may be significant in determining nanoscale reaction success.

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