This highly significant alternative splicing event overlap between the datasets suggests that PRMT5 inhibition and methionine dependence impact similar gene pathways and splicing factors that promote cell proliferation defects. 4 Discussion Methionine dependence of cancer has been known for over 40 years, yet cellular pathways that contribute to this common metabolic addiction of cancer cells are only beginning to be identified.
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Nutrient control of splice site selection contributes to methionine addiction of cancer.
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