Updated insights into the impact of adjuvant chemotherapy on recurrence and survival after curative resection of liver or lung metastases in colorectal cancer: a rapid review and meta-analysis.

World J Surg Oncol · 2025 · PMC11834510 · PMID 39966950

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

a positive trendp = 0.06so close (0.05 < p ≤ 0.1)

This meta-analysis showed a positive trend in OS for the AC group compared to that for the surgery-alone group (HR 0.86, 95% CI: 0.73–1.01; p = 0.06), but the difference was insignificant.

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a notable trendno p-value reported

In cases of liver metastasis, DFS significantly improved in the AC group compared with that in the surgery-alone group (HR 0.75, 95% CI: 0.65–0.87), and OS showed a notable trend toward improvement; however, there was no statistically significant difference between the groups (Fig. 7 a, b).

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