The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells.

To investigate mitochondrial integrity, we used a JC1 assay, which allows the assessment of mitochondrial membrane potential, and we demonstrated that only the HR cells, when treated with higher concentrations of HQ, showed a decreasing trend in mitochondrial membrane depolarization ( Figure 3B ).

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