Bispecific antibody simultaneously targeting AGR2 and PD1 mediates cytotoxic T-cell-induced antitumor response in AGR2-dependent manner and inhibits AGR2-induced PDL1 upregulation.

Sci Rep · 2025 · PMC11840037 · PMID 39971962

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highly significantno p-value reported

We observed the highly significant cell membrane disruption of AGR2-overexpressing H460 (Fig. 1 B - last column) and MCF7 (Fig. 1 C - before last column) cells in the BsAb-treated group.

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