Evaluation of mucosal adjuvants to chitosan-nanoparticle-based oral subunit vaccine for controlling salmonellosis in broilers.

Front Immunol · 2025 · PMC11840259 · PMID 39981235

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an increasing trendno p-value reported

At DPC10, there was an increasing trend in IFN-γ gene expression in mChitosan (OMP+FLA)/FLA-NP, mChitosan (OMP+FLA)/FLA-NP WCL 10 and 50 μg/dose, mChitosan (OMP+FLA)/FLA-NP GMP 50 μg/dose, and commercial vaccine groups compared to the mock and mock challenge groups ( Figures 5G, H ).

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a decreasing trendno p-value reported

The frequency of B cells (CD3 - BU1 + ) increased numerically in mChitosan (OMP+FLA)/FLA-NP WCL 2.5, 10, and 50 μg/dose and GMP 2.5 μg/dose and without any adjuvant vaccinated groups at DPC4 ( Figures 6A, B ), which was in a decreasing trend in all of those vaccinated groups by DPC10 ( Figures 6C, D ).

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