Glucocorticoid exposure-induced alterations in epigenetic age from human preterm infants and human lung fibroblasts and hippocampal neuronal cells.

We observed that DNAm age displayed an increasing trend line ( P = 0.26, Fig. 2 A) in the IMR-90 cells after treatment with 100 nM cortisol for 4 h; however, DNAm age displayed a significant decrease ( P = 0.004) in the cells after treatment with 500 nM relacorilant for 4 h, a selective glucocorticoid receptor modulator that competitively antagonizes the effects of cortisol activity, as compared with the untreated vehicle or the cortisol treatment.

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