highly significantP<0.001
We defined P<0.0001 as a highly significant difference (**), P<0.001 as a significant difference (*), and P≥0.001 as not significant (n.s.).
We defined P<0.0001 as a highly significant difference (**), P<0.001 as a significant difference (*), and P≥0.001 as not significant (n.s.).