highly significantp-value of <0.0001
The amount of MON deposition under infinite-dose conditions was examined from three formulations: MON-NLC, MON-NLC gel, and MON in water across the epidermis, dermis, and the receiver chamber of the Franz diffusion cell after 24 h application ( Figure 11 ). A significant finding was that the MON-loaded NLC gel left much less MON on the skin surface (59.50 ± 505.81 ng/cm2) as extracted from the skin wash compared to the MON-loaded NLC (14313.11 ± 118.88 ng/cm2), with a highly significant p-value of <0.0001.