Renal clearance estimated by rubidium-82 positron emission tomography/computed tomography and technetium-99m-mercaptoacetyltriglycine clearance infusion technique.

Clin Physiol Funct Imaging · 2025 · PMC11847954 · PMID 39988762

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

just misses statistical significancep = 0.053so close (0.05 < p ≤ 0.1)

The correlation in the placebo period reached statistical significance ( p = 0.019) whereas the correlation in the spironolactone period just misses statistical significance ( p = 0.053).

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a positive trendno p-value reported

These show no obvious flow‐dependent trend for changes in 82 Rb clearance measurements, whereas a positive trend is observed for changes in [ 99m Tc]Tc‐MAG3 clearance measurements, indicating that this method appears to be clearance‐dependent. 4 DISCUSSION In this study, we have made a first attempt to validate 82 Rb PET/CT for renal perfusion estimation in humans using the reference method available in our laboratory: [ 99m Tc]Tc‐MAG3 clearance constant infusion technique. 4.1 Evaluation of the renal clearances of 82 Rb and [ 99m Tc]Tc‐MAG3 In both treatment cycles, renal 82 Rb clearance correlated positively with renal [ 99m Tc]Tc‐MAG3 clearance which is an accepted approximate estimator of ERPF.

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