qRT-PCR results showed a nonsignificant trend toward increased CASP8 transcript levels in end-stage frontal cortex autopsy tissue from a small cohort of CASP8 -GGGAGA EXP (+) versus CASP8 -GGGAGA EXP (−) cases ( SI Appendix , Fig.
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<i>CASP8</i> intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk.
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