a decreasing trendP = 0.002
Figure 1 (a) shows that there were no changes in overall adherence over time ( P = 0.108) and adherence in ED-PrEP users ( P = 0.270), whereas D-PrEP users showed a decreasing trend (from 78% in the first follow-up to 73.1% after 12 months, P = 0.002).