Barely Significant
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Gynura procumbens leaf extract-loaded self-microemulsifying drug delivery system offers enhanced protective effects in the hepatorenal organs of the experimental rats.

PLoS One · 2025 · PMC11849907 · PMID 39992935

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highly significantno p-value reported
Nevertheless, due to the possibility of incomplete protection or excessive generation of reactive oxygen species (ROS), the inclusion of dietary antioxidants as supplementary protective mechanisms becomes highly significant [ 7 , 8 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.